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Feature Article: A Simple Method For Evaluating Filtration Membranes

BioProcess International

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Description

By Stanley Peters

Membrane filters can be evaluated for the amount of fluid that can be filtered per unit area of filter media (throughput) at the bench scale using disposable or small membrane discs in reusable filtration devices (test housings). These devices typically range in diameter from 25 mm to 90 mm, with 47 mm being the most commonly used. A laboratory often has more than one type of 47-mm disc housing for testing membrane filters. Even though two different test housings may accept the same diameter membranes and seal the membranes with the same size O-ring, they may produce significantly different throughput test results. The primary cause for variability in throughput is differences in the effective filtration area (EFA) of membranes evaluated in the test housings.

Reprinted with permission from BioProcess International 5(3):50-55 (March 2007)